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Surakarta city which is transitment point for economic activity, education and tourism with the surrounding area, so raising activity of the traffic on each type of land use followed by an increase in ambient carbon monoxide concentrations would potentially cause carboxyhemoglobin in the blood that affect to community health.

The purpose of this research is to 1) mapping the distribution, 2) determine spatial patterns, and 3) how the ambient concentrations of carbon monoxide and potential carboxyhemoglobin in the blood on different of environmental, social and economic community.

Research was conducted by mapping the distribution of the concentration of carbon monoxide in ambient and potential carboxyhemoglobin in blood, then spatial pattern with spatial autocorrelation analysis using Arc.GIS 9.3, while the interpretation of environmental conditions Quickbird image and socio-economic measures carried out directly in the field.

Ambient concentrations of carbon monoxide and potential carboxyhemoglobin in the blood in Surakarta City has a random spatial pattern, then one of the locations with the highest concentrations of carbon monoxide at 9,2 ppm and potentially cause carboxyhemoglobin at 1.477% in blood with exposure during the first hour of being at the location of trade, thats Jongke market is dominated by trade, education and services.

Keywords: Ambient Carbon Monoxide, Carboxyhemoglobin, Autocorrelation, Quickbird Image, Social and Economic Condition